By E. H. Fischer, N. F. Zander, J. Lorenzen, C. Dadabay, D. E. Cool (auth.), Ludwig M. G. Heilmeyer Jr. (eds.)
ISBN-10: 3642782477
ISBN-13: 9783642782473
ISBN-10: 3642782493
ISBN-13: 9783642782497
Approximately each mobile task, reminiscent of cellphone development, proliferation, protein synthesis, and nuclear department, is regulated via protein phosphorylation/dephosphorylation on tyrosine residues as initiation events.Synchronization happens via interplay of protein tyrosine kinases and phosphatases. This publication unveils sign pathways that attach extracellular indications with alterations of phosphorylation country of aim proteins permitting coordinated and built-in modulation of mitogenic signalling. in particular, cascades concerning protein serine/threonine kinases and connections to phosphoinositides derived moment messengers are mentioned.
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M. (1984). Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites. Nature, 310, 589-91. Keller, G. F. (1989). Expression of v-src induces a myeloproliferative disease in bone-marrow-reconstituted mice. , 3, 827-37. D. E. (1991). T cell antigen receptor activation pathways: The tyrosine kinase connection. Cell, 64, 875-878. L & Shalloway, D. (1988). Regulation by the autophosphorylation site in overexpressed pp60c-src . Mol. Cell.
Altered phosphorylation and activation of pp6OC-src during fibroblast mitosis. Cell, 52, 801-810. V. (1992). Growth factor signalling: Where is the specificity? Cell, 68, 995997. , Merrill, J. E. (1991). Structural elements that regulate pp59iYn catalytic activity, transforming potential, and ability to associate with polyome-virus middle-T antigen. I. , 65, 170-179. A. M. (1991). Regulation of T cell receptor signalling by a src family protein-tyrosine kinase (p59iY n). Cell, 65, 281-291. A. (1990).
1991). SH2 and SH3 domains: Elements that control interactions of cytoplasmic signalling proteins. Science, 252, 668-674. S. & Halegoua, S. (1991). Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions. J. , 115, 809-819. , Ulug, E. A. (1990). Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell, 62, 481-492. , Wang, L-H. & Brugge, LS. (1987). The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.
Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling by E. H. Fischer, N. F. Zander, J. Lorenzen, C. Dadabay, D. E. Cool (auth.), Ludwig M. G. Heilmeyer Jr. (eds.)
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