By Professor Dr. A. S. Spirin, Dr. L. P. Gavrilova (auth.)
ISBN-10: 3540046550
ISBN-13: 9783540046554
ISBN-10: 3642884466
ISBN-13: 9783642884467
This monograph is neither a ancient define of the improvement of the recommendations of protein biosynthesis and the constitution and features of the ribosomes, nor an exhaustive survey of the literature on those questions. The monograph is predicated upon an research of the fashionable traits during this box. the aim of the monograph was once to formulate roughly generalized representations of the constitution and" functionality of the ribosome, as we envision it at present day. it can be that this try is untimely for a couple of purposes, and the ideas defined the following will very quickly be revised. still, regardless of this chance, we think it to be beneficial to adopt this try for the next purposes: to begin with, the undertaken research may possibly reduction within the comprehension of the large mass of tremendous scattered experimental information at the ribosomes almost immediately on hand; secondly, in any occasion, no matter if lots of the thoughts defined quickly develop into obselete, they could nonetheless function a stimulus for an entire sequence of experiments; and thirdly, we are hoping that a number of the innovations defined will nonetheless stay basically right and comparatively sturdy. In view of the aforementioned, we should always make the next reservations. firstly, we made no try to cite all of the literature at the difficulties mentioned, yet thought of it enough to demonstrate some of the premises with one or numerous pattern references.
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Extra resources for The Ribosome
Sample text
This index, the critical Mg++ content, below which given ribosomes dissociate into subparticles - may be denoted as the first critical level of Mg++ content in ribosomal particles. The stability of the ribosomal subparticles themselves is maintained at a substantially lower Mg++ content. 15 micro mole per micromole of phosphorus (LANSINK, 1964). This residual Mg++ is extremely firmly retained by the subparticles themselves. If this content is reduced even more by treatment with chelating agents (EDTA), then the native structure of the subparticles begins to break down.
Therefore, depending upon their content in the ribosomes, the critical levd of the Mg++ content may evidently differ and vary somethat even for ribosomes from the same species. Polyamines, as a component of the ribosomes, have been studied most detailly in preparations of ribosomes from E. coli. Both the qualitative assortment and their quantitative content vary somewhat according to the data of different authors. , that this component of the ribosome is not so constant, not so strictly fixed in quantity and composition as others.
In contrast to bacteria and higher plants, among lower plants, belonging to the Eukaryotes, there may evidently be more substantial variations of the nucleotide composition of ribosomal RNA's, depending upon the species. In fungi, for example, the composition of the total RNA, evidently reflecting chiefly the composition of the Table 4. , 1960). , 1966). Here, as a rule, substantial differences are noted in the nucleotide composition of the two classes of high-molecular weight ribosomal RNA: in most cases analysis shows an appreciably larger content of A and U and a smaller content of G and C in preparations of 18 S RNA in comparison with 28 S RNA.
The Ribosome by Professor Dr. A. S. Spirin, Dr. L. P. Gavrilova (auth.)
by John
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