By Eckhard Jankowsky
ISBN-10: 1849732213
ISBN-13: 9781849732215
RNA helicases and RNA helicase-like proteins are the most important staff of enzymes in eukaryotic RNA metabolism and even if they're topic to severe ongoing study there's a lot confusion approximately functionality and type of those enzymes. even though those enzymes are crucial for almost all techniques regarding RNA, there's no evaluation detailing constitution, functionality and/or organic roles of those pivotal proteins. This publication presents the 1st accomplished and systematic assessment of biology, mechanism, and constitution of RNA helicases and RNA helicase-like enzymes. learn into RNA helicas learn more... content material: Foreword: present in translation - the invention of the 1st RNA helicase, eIF4A; bankruptcy 1: An creation to RNA helicases: Superfamilies, households, and significant topics; bankruptcy 2: The dynamic existence with DEAD-box RNA helicases; bankruptcy three: Mechanisms of DEAD-box Proteins in ATP-dependent strategies; bankruptcy four: The Biology of DEAH/RHA Proteins and Their Mechanism of motion; bankruptcy five: RIG-I-like RNA Helicases: Multidomain Proteins in Antiviral Innate Immunity and Processing of Small Regulatory RNAs; bankruptcy 6: Ski2-like proteins: Biology and Mechanism; bankruptcy 7: Viral DExH Proteins; bankruptcy eight: Superfamily 1 RNA helicases: Biology and Mechanism; bankruptcy nine: Hexameric Viral RNA Helicases; bankruptcy 10: Transcription Termination issue Rho: a Ring-shaped RNA Helicase from micro organism summary: A key reference for lecturers, complex scholars, researchers and execs operating in or becoming a member of this box. learn more...
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Extra info for RNA helicases
Example text
19 Accordingly, both SF1 and 2 RNA helicases generally show no sequence specificity when binding and unwinding RNA in vitro. 3). 31,66 Many eukaryotic SF1 proteins also appear to function in DNA metabolism, yet several important eukaryotic SF1 RNA helicases have been identified (Chapter 8). SF1 helicases are also encoded by a large number of ( þ ) single-stranded RNA viruses. 65 Given their similar fold, SF1 and SF2 helicases are assumed to share significant aspects of their molecular mechanism,16,32,61 but the extent of such similarities for RNA helicases of both superfamilies is currently unknown.
Contacts to residues on the RNA are represented by the dotted lines. The colour coding emphasises potential functional similarities between motifs located in domains 1 and 2 (IV – domain 2 and Ia – domain 1, V – domain 2, and Ic – domain 1, IVa – domain 2 and Ib – domain 1). The dots underneath the key residues indicate the number of amino acids in the corresponding sequence motifs. Filled dots indicate a side-chain contact, dots with coloured rim show a backbone contact to the RNA. White dots represent intervening residues.
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RNA helicases by Eckhard Jankowsky
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