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Moreover, the CA polymers are easily detached from soft tissues because of their high stiffness. Therefore, higher viscosity and longer set time of CA as well as higher flexibility of the CA polymers are strongly desirable in order to solve these problems. There are patents for industrial applications of the mixtures of CA with plasticizers 7 and thickening agents,B but no work has been reported 53 for the plasticized CA which is to be used as surgical adhesives. Recently, we have reported that D, L-lactide polymers mixed with CA provide a wide range of viscosity and polymerization time.

20 These compounds can react with reactive hydrogen groups such as -OH, -SH or -NH2 of collagen, yielding covalent bonds with the tissue surface. The resulting adduct has residual double bonds which can polymerize under suitable conditions to yield polymeric side chains grafted onto the collagenous tissues. The objective of this study was (1) to synthesize oligomers of [IEM] orland [TMI] with various acrylate or methacrylate esters or vinyl monomers, (2) to characterize the resulting -NCO containing compounds and (3) to determine their adhesion to hard and soft tissues.

IOL surfaces with reduced tissue adhesion and abrasion therefore appear desirable to minimize any chance of such chronic complications. This study was aimed at developing tests to evaluate differences in tissue damage by various IOL materials. A primary objective was to assess the potential advantages of permanent, lubricious, hydrophilic surface modifications of PMMA. Using a corneal endothelium damage test instrument which we have previously described,3 the hydrophilic polymer surface modification of PMMA used in this study was shown to reduce endothelium cell loss from ca.

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