By Wolfgang Drexler, James G. Fujimoto
ISBN-10: 3319064185
ISBN-13: 9783319064185
ISBN-10: 3319064193
ISBN-13: 9783319064192
ISBN-10: 3319064207
ISBN-13: 9783319064208
Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is a robust imaging approach that permits non-invasive, in vivo, excessive solution, cross-sectional imaging in organic tissue. among 30 to forty Million OCT imaging approaches are played in step with 12 months in ophthalmology. the final industry is anticipated at greater than 1/2 Billion USD.
A new new release OCT expertise used to be constructed, dramatically expanding solution and velocity, reaching in vivo optical biopsy, i.e. the visualization of tissue architectural morphology in situ and in actual time. useful extensions of OCT expertise permit non-invasive, intensity resolved useful review and imaging of tissue.
The ebook introduces OCT expertise and functions not just from an optical and technological point of view, but in addition from the biomedical and scientific viewpoint. This moment variation is broadly prolonged and covers considerably extra themes then the 1st variation of this booklet. The chapters are written via top foreign study teams, in a method understandable to a large viewers. it is going to be of curiosity not just to physicists, scientists and engineers, but in addition to biomedical and medical researchers from diverse clinical specialties.
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Additional info for Optical Coherence Tomography: Technology and Applications
Sample text
14 Schematic of OCT instrument design for retinal imaging. An objective lens relay images the retina to a plane in the OCT instrument. Operator viewing of the fundus is performed by imaging with a video camera. Computer-controlled galvanometer scanning mirrors positions and scan the OCT beam. A relay lens focuses the OCT beam onto the image plane, and the objective lens directs the OCT beam through the pupil onto the retina. The OCT beam is focused on the retina by adjusting the objective lens.
This instrument was used in the New England Eye Center to perform the first clinical studies of OCT in ophthalmology [25–27, 51]. Several thousand patients were imaged in cross-sectional as well as longitudinal studies during the mid-1990s. G. Fujimoto and W. Drexler Fig. 13 Photograph of an early retinal imaging prototype instrument. The OCT system is interfaced with a slit lamp biomicroscope. The OCT beam is scanned using a pair of galvanometer-actuated mirrors. 14 shows a schematic diagram of the optical design for retinal imaging.
Early studies of endoscopic OCT imaging suggested the ability of OCT to differentiate GI pathologies such as the Barrett’s esophagus, adenomatous polyps, and adenocarcinoma [57, 65, 67–73]. However, the development of OCT imaging for cancer detection remains extremely challenging. Conventional histopathology is an extremely powerful diagnostic technique because it enables the use of selective stains to enhance contrast between different cellular or tissue structures. Histology also provides extremely fine image resolutions, enabling the visualization of not only larger scale tissue architectural morphology but also subcellular structure.
Optical Coherence Tomography: Technology and Applications by Wolfgang Drexler, James G. Fujimoto
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