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Read e-book online Liver Carcinogenesis: The Molecular Pathways PDF

By George G. Skouteris (auth.), George G. Skouteris (eds.)

ISBN-10: 3642792154

ISBN-13: 9783642792151

ISBN-10: 3642792170

ISBN-13: 9783642792175

During the final years a lot realization has been given to the research of the jobs of particular progress modulators performing on liver phone populations. HGF features as a pleotropic think about the liver in addition to in different extrahepatic tissues. The hepatic stem cellphone compartment is assumed to play a massive function in liver tissue recovery. Mechanisms of telephone development and cellphone demise of the liver are defined intimately, with specific emphasis on apoptosis. The services of HBV-pX protein and the jobs of hepatitis B virus gene expression relation to hepatocellular carcinoma are mentioned. strategies for acquiring human and nonhuman hepatocytes and different liver mobilephone forms and for effective move and expression of genes in hepatocytes and liver-derived mobilephone traces are presented.

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Additional resources for Liver Carcinogenesis: The Molecular Pathways

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HGF protein is located in nonparenchymal liver cells. ,1992). These results implicate the presence of humoral factor which induces HGF expression in distant intact organs in response to hepatic injuries and that HGF may trigger liver regeneration by an endocrine mechanism, in addition to a paracrine mechanism functioning in local injured sites. Based on these findings, we prepared a large amount of human recombinant HGF and injected into experimental animals with various types of hepatic injuries.

Looquonc. J • (31 ••oJ '. ln /kholn (34kOJ Fig. 1. Schematic structures of HGF gene, HGF mRNA, prepro-HGF, and mature HGF. 37 (3) Structure-function relationship Among various growth factor, HGF is unique in possessing a structure of four kringle domains and a serine protease-like domain. , 1991a). Deletion of the first or second kringle domain led to an almost complete inactivation of HGF activity to stimulate DNA synthesis of hepatocytes in primary culture. Likewise, deletion of N-terminal hairpin structure almost completely inactivated biological activities of HGF.

And Nakamura T. (1991) Purification and characterization of hepatocyte growth factor from injured liver of carbon tetrachloride-treated rats. lBiochem. 109:8-13. , Vande Wounde GF. and Aaronson SA. (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251:802-804. , Chedid M. and Aaronson SA. (1991) Identification of a competitive antagonist encoded by an alternative transcript. Science 254: 1382-1385. ,Perryman M. and Furlong R. (1989) Purification of scatter factor, a fibroblast-derived basic protein that modulates 48 epithelial interactions and movement.

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Liver Carcinogenesis: The Molecular Pathways by George G. Skouteris (auth.), George G. Skouteris (eds.)


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