By E. P. Slater, M. Beato (auth.), Priv.-Doz. Dr. Armin Steinmetz, Prof. Dr. Jürgen Schneider, Prof. Dr. Hans Kaffarnik (eds.)
ISBN-10: 3540559957
ISBN-13: 9783540559955
ISBN-10: 3642848559
ISBN-13: 9783642848551
An intimate relation among hormones and lipoprotein metabolism has been recognized for a very long time specially from hormone-deficiency or -overproduction syndromes. The mechanisms in which hormones impact lipid metabolism became a box of significant curiosity in sci ence. The extra we know about mobile hormonal activities the higher we comprehend regulatory methods and phenomena occuring in sufferers. the current e-book summarizes facts mentioned at a world Meet ing at Marburg, Germany, on "Hormones in Lipoprotein Metabolism". It was once an try to pull jointly wisdom in simple technological know-how from the mode of motion of hormones the entire approach to medical visual appeal of hor monal problems related to lipoprotein metabolism. hence information on molec ular biology, on hormonal legislation of apolipoprotein synthesis, on lipoprotein receptors and enzyme induction are mentioned including the big box of oral contraceptive use, postmenopausal estrogen sub stitution, lipid issues in diabetes mellitus, in thyroid disorder, in adrenal insufficiency and in glucocorticoid program. we're conscious of the truth that such an summary can't be whole yet may still function a suite of information and concepts for these drawn to hormonal rules of lipid metabolism. We thank all authors for taking an additional attempt in writing up their displays and hence making this version attainable. We additionally thank Bristol-Myers-Squibb for beneficiant help of the assembly and of the ultimate booklet. Marburg, Germany ARMIN STEINMETZ JURGEN SCHNEIDER HANS KAFFARNIK Contents Molecular Biology Chairmen: D. J. Rader, A.
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10. Davidson NO, Powell LM, Wallis SC, Scott J (1988) Thyroid hormone modulates the introduction of a stop codon in rat liver apolipoprotein B messenger RNA. J BioI Chern 263:13482-13485. 11. Davies MS, Wallis SC, Driscoll DM, et al. (1989) Sequence requirements for apolipoprotein B RNA editing in transfected rat hepatoma cells. J BioI Chern 264: 13395-13398. 12. Davis RA, Boogaerts JR, Borchardt RA, Malone-McNeal M, ArchambaultSchexnayder J (1985) Intrahepatic assembly of very low density lipoproteins.
Interestingly, in support of this interpretation it was recently reported that patients with coronary heart disease also have a prolonged postprandial hypertriglyceridemia [11]. In summary, our data provide evidence that in patients with type2 diabetes mellitus a prolonged postprandial hypertriglyceridemia may exist even when fasting values are normal. Thus, the actual state of the triglyceride metabolism in diabetics can not be judged exactly by determining fasting values only. Postprandial Course of Triglycerides and the Atherogenic Lipoprotein 43 References 1.
J Lipid Res 22:307-22. 2. Abrams JJ, Grundy SM (1981) Cholesterol metabolism in hypothyroidism and hyperthyroidism in man. J Lipid Res 22:323-38. 3. Baum CL, Teng B, Davidson N (1990) Differential regulation of hepatic apolipoprotein gene expression and apoB-100 mRNA editing following alterations in hepatic lipogenesis. Clin Res 38:482A. 4. Blackhart BD, Ludwig EM, Pierotti VR, et al. (1986) Structure of the human apolipoprotein B gene. J BioI Chem261:15364-15367. 5. Bostrom K, Lauer SJ, Poksay KS, Garcia Z, Taylor JM, Innerarity TL (1989) Apolipoprotein B48 RNA editing in chimeric apolipoprotein EB mRNA.
Hormones in Lipoprotein Metabolism by E. P. Slater, M. Beato (auth.), Priv.-Doz. Dr. Armin Steinmetz, Prof. Dr. Jürgen Schneider, Prof. Dr. Hans Kaffarnik (eds.)
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