Chromosomal Alterations: Origin and Significance by D. Schulte-Frohlinde (auth.), Professor Dr. Günter Obe, PDF

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M cervicolor. M cookii. M An Inherited Homogeneously Staining Region in the House Mouse 39 hortulanus, M macedonicus, M musculus and M spretus. In the mouse genome, a different cluster of "large repeat sequences" was found in band B3 or D of chromosome 8 (Boyle and Ward 1992) and another cluster, consisting of "long complex repeat units", was detected in band A3 of the mouse X chromosome (Nasir et al. 1990). Thus, there are hints that this type of sequence organization may prove to be a regular component of a genome if searched for.

F. Mullenders et al. 2 Organization of Chromatin In interphase nuclei the 30 nm chromatin filaments are folded into DNA loops of approximately 60 kb that are attached at their base to a nuclear skeleton termed the nuclear matrix (Pienta et al. 1991). The nuclear matrix is the residual proteinaceous structure of the nucleus and consists of peripheral lamins and pore complexes, an internal ribonucleic protein network and residual nucleoli. Different experimental approaches have revealed compelling evidence that this skeleton plays a central role in DNA replication, transcription and RNA processing (Dijkwel et al.

Lengauer, H. Scherthan, T. Ried and M. R. Speicher Institute for Human Genetics and Anthropology, 1m Neuenheimer Feld 328, D-69120 Heidelberg, Federal Republic of Germany IGerman Cancer Research Center, Section Organization of Complex Genomes, 1m Neuenheimer Feld 280, D-69120 Heidelberg, Federal Republic of Germany 1 Introduction During the last decade strong evidence has been accumulated for a causal relationship between specific genetic alterations and the abnormal differentiation state and growth behaviour of malignant cells.

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