By Ludwig M. G. Heilmeyer Jr. (auth.), Ludwig M. G. Heilmeyer Jr. (eds.)
ISBN-10: 3642751423
ISBN-13: 9783642751424
ISBN-10: 364275144X
ISBN-13: 9783642751448
In eukaryotes many very important mobile services like metabolism, motility, secretion, progress, differentiation are finally regulated via protein phosphorylation/dephosphorylation. Extracellular indications which set off thesechanges regulate protein kinases and protein phosphatases. it's the goal of this quantity to unveil sign networks which attach extracellular indications through moment messengers with chages of the phosphorylation kingdom of aim proteins.
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Example text
N-l) /2) is also small and conformational changes require a large relative change in energy (~E/E). The notion of "the" structure or of a few distinct conformations is valid. The small number of parameters and large constraints make computational predictions of conformation very powerful. Note that, although several thousand structures of organic compounds are known to very high resolution, relatively little use of this information is made in organic chemistry textbooks. The reason is partly that substitutions, for instance, which have large effects on 20 rate constants lead to geometric effects that are often at the limit of the precision that can be achieved.
Note that whereas it is very fashionable to look for sequence homology much less effort is made looking for analogies although this may be more productive if one wants to learn to design molecular devices. Analogous organs, like the eyes 24 of very distant species, like flies and humans, tell more about the fundamental physical constraints of vision than a detailed comparison of eyes in closely related species. The same is probably true at the molecular level. There are thus intrinsic limitations to a geometrical structural approach which can only be circumvented by integrating the experimental and theoretical approaches that give information about the changes in the forces that act upon the system.
Therefore, we have established a series of new methods which permit the localization of phosphoserine, phosphothreonine and phosphotyrosine in the lower picomolar range without the need of radioactive labelling. ,. PHOSPHOSERINE A highly specific method for determination of phosphoserine is the chemical modification to S-ethyl-cysteine. This amino acid derivative can be determined by amino acid or sequence analysis (Meyer et al. 1990, 1991 a). Fig. 1 shows the amino acid analysis of a Lys-C-peptide from the beta subunit of phosphorylase kinase after modification of the endogenously present phosphoserine to S-ethyl-cysteine.
Cellular Regulation by Protein Phosphorylation by Ludwig M. G. Heilmeyer Jr. (auth.), Ludwig M. G. Heilmeyer Jr. (eds.)
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