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Additional info for Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses. Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27–29, 1981

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J. , 2 2 , 5 0 7 - 5 1 2 . M e v e s , H. and Y. P i c h ó n ( 1 9 7 7 ) . T h e e f f e c t of i n t e r n a l and e x t e r n a l 4 - a m i n o p y r i d i n e on the p o t a s s i u m c u r r e n t s in i n t r a c e l l u l a r l y p e r ­ fused squid g i a n t a x o n s . J. P h y s i o l . ( L o n d . ) , 2 6 8 , 5 1 1 - 5 3 2 . Nonner, W. (1969). A n e w v o l t a g e c l a m p m e t h o d for R a n v i e r n o d e s . Pflügers Arch. , 309, 1 76-192. P e l h a t e , M . , B. H u e , Y. P i c h ó n and J.

W e are i n t e r e s t e d in t h e s e d r u g s m a i n l y as t o o l s to e x p l o r e p o t a s s i u m c h a n n e l s . In a p r e v i o u s study w e h a v e i n v e s t i g a t e d 4-AP b l o c k as a f u n c t i o n of m e m b r a n e p o t e n t i a l and d r u g c o n c e n t r a t i o n (Wagner and 29 30 W. -Η. Wagner and J. Schmidtmayer U l b r i c h t , 1 975 a; U l b r i c h t and W a g n e r , 1976). T h i s p a p e r w i l l be in p a r t r e v i e w of these e a r l i e r f i n d i n g s b u t a l s o p r e s e n t n e w r e s u l t s w i t h 3,4-DAP, o n r e s t o r a t i o n of 4-AP b l o c k at r e s t and o n p o s s i b l e 4-AP-TEA i n t e r a c t i o n .

7 3 . 1 6 . 4 © C . calculation of r ( t ) . Currents were also measured in a modified experiment i l l u s t r a t e d in F i g . 7 w h e r e t2 w a s v a r i e d for d i f f e r e n t V2 a n d I 3 (O)/Ii (O. 5 ) , c o r r e s p o n d i n g t o r 3 (0)/r-j ( 0 . 5 ) , w a s p l o t t e d a s a f u n c tion of t 2 . T h e g r a p h s h o w s a c l e a r d i f f e r e n c e a l r e a d y b e t w e e n V2 = 0 and V2 = 10 m V ; t h e v a l u e s of T ¿ , d e c r e a s i n g w i t h i n c r e a s i n g V 2 , a r e g i v e n in t h e legend.

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